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In Episode 276, Kyle kicks things off with a brunch story involving an oversized, impossible-to-handle coffee mug and a series of well-intentioned but clumsy attempts to make it right.

The episode then shifts gears with a fun and thought-provoking compilation of answers from past guests to the question: If you ruled the world, what would you change? Responses range from practical ideas like increasing accessibility and reducing barriers, to grand visions of kindness, open science, and even perfect weather in Pennsylvania. Each guest’s answer serves as a reminder of how personal experiences shape our view of what the world could be.

The episode wraps up with heartfelt thank-you notes: Kyle expresses his gratitude to all his generous donors by adding each of their names to his fundraising “spirit chain,” while Sean thanks Santino, a colleague who went out of his way to share how much he enjoyed Sean’s recent corporate presentation. These moments of appreciation highlight the power of connection and acknowledgment in both personal and community-driven efforts.

This episode is a reminder that even small gestures can have a world-changing impact.

Links and Resources

• Katie, Team Telomere
• Heidi, Association for Creatine Deficiencies (ACD)
• Jay, Write on, Fight on
• Rivki, CTNNB1 Connect & Cure
• Kendall, Icon
• Erin, Rea of Hope